Within three days, two different strains of the coronavirus are not only started to stick in the lungs of the patient, but also causes his weight to fall.
For the first time, Indian scientists have uncovered the mystery of double mutation. Through the study, scientists have revealed that the condition of corona patients in the country is getting serious because at least one-fourth of their lungs are getting infected by the virus before the investigation report comes.
Scientists were surprised when they found mutations called D111D, G142D, L452R, E484Q, D614G, and P681R in strain B1.617 with double mutations.
Scientists from the Pune-based National Institute of Virology (NIV), after studying the mice, discovered that the patient becomes seriously ill on the third day after infection. By giving double mutations to the mice, they discovered that they had started spluttering on the third day itself. A high infection load of the virus was found in them, which directly indicates the fatal situation.
Senior Scientist Dr. Pragya Yadav said that two variants of the virus have been identified in the strain named B.1.617. In this strain, eight amino acid changes have been observed in the spike region of the virus. Seriousness is being detected by having more than one subfamily. Where did this variant come from? It still remains a mystery.
It has been found so far in 21 countries including India, but the reason is not known there. According to the Ministry of Health’s NCDC, 3,532 severe variants have been detected so far in genome sequencing of 13,000 samples, of which 1,527 have found a double mutation variant.
this study has been published in the medical journal BioRXIV. According to scientists, so far new changes of the coronavirus were being detected in the country through genome sequencing but no one had accurate information about its effects. That’s why NIV scientists started this study and shortly after, they started seeing results.
Genome sequencing of 733 samples from 25 November 2020 to 31 March 2021 found double mutation B1.617 in 273 samples. While 73 found B1.36.29,67 in B1.1.306, 31 in B1.1.7 and 24 samples in B1.1.216.
Scientists then began investigating the viral load and pathogenic potential of B1.617 in golden hamsters mice of Syria. During testing on nine mice in two different groups, one was given B1 (D614G) and the other group received B1.617 mutations, after which the mysterious effects of double mutations were detected.